Challenges during drug development, EMA and FDA guidance
This topic discusses use cases and best practices to meet the regulatory guidance and requirements, e.g. How to evaluate Ki and IC50? Example slides
- 5 months ago
Does the transporter scientific community miss online tools, databases?
List of available online services, or missing databases search engines facilitating transporter scientific community.
- 5 months, 4 weeks ago
Importance of transporters during drug development
Apart from P-gp, what other transporters should be thoroughly investigated? BCRP and OATP are enough or do we need to go deeper?
- 5 months, 2 weeks ago
Interspecies variablity on transporter protein function
This topic collects information on the possibility of extrapolation to human transporter protein function, in addition to discussing interspecies differences.
- 11 months, 2 weeks ago
Best practices, use cases, best technologies, its application used in conjunction with “in vitro - in vivo extrapolation” (IVIVE) of ADME data that can provide a useful starting point to understand and extrapolate PK and dose across different species, populations, and disease states.
- 9 months, 3 weeks ago
- Challenges during drug development, EMA and FDA guidance